Genomic Assays in Node Positive Breast Cancer Patients: A Review

Survival after Node-positive Breast Cancer

The goal of screening for breast cancer is to identify cancers when they are at a curable stage. The prospect for cure depends in turn on the extent to which the cancer has spread at diagnosis. If a breast cancer is entirely contained within the breast (that is, if no subclinical metastases have occurred), then complete excision through mastectomy or breastconserving surgery is expected to be c...

Adjuvant docetaxel for node-positive breast cancer.

BACKGROUND We compared docetaxel plus doxorubicin and cyclophosphamide (TAC) with fluorouracil plus doxorubicin and cyclophosphamide (FAC) as adjuvant chemotherapy for operable node-positive breast cancer. METHODS We randomly assigned 1491 women with axillary node-positive breast cancer to six cycles of treatment with either TAC or FAC as adjuvant chemotherapy after surgery. The primary end p...

BIRC5 Genomic Copy Number Variation in Early-Onset Breast Cancer

Background: Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) gene is an inhibitor of apoptosis that expresses in human embryonic tissues but it is absent in most healthy adult tissues. The copy number of BIRC5 has been indicated to be highly increased in tumor tissues; however, its association with the age of onset in breast cancer is not well understood. Methods: Forty tumor tiss...

Factors Affecting axillary lymph node involvement in patients with breast cancer

Background: Breast cancer is the most commonly diagnosed and the leading cause of cancer death among females worldwide. The rate of breast cancer incidence among Iranian women is 17% of all cancers, it has been ranked first in Iran. This study aimed to investigate the factors affecting axillary lymph node involvement in female patients with breast cancer. Methods: A cross-sectional study was c...

HER2 Testing in Invasive Breast Cancer: a Comparison between Immunohistochemistry and FISH Assays